Sophia may refer to:
- Sophia (Fire Emblem) - A character from the Fire Emblem series.
- Sophia (Mario Tennis) - A character from Mario Tennis: Power Tour.
- Sophia (Panel de Pon) - A character from Nintendo Puzzle Collection.
- Sophia (Professor Layton) - A character from Professor Layton and the Diabolical Box
- syn Sophia - A video game company.