Serena may refer to:
- Serena (Animal Crossing) - a character from Animal Crossing: City Folk.
- Serena (Dragalia Lost) - a character from Dragalia Lost.
- Serena (Pokémon Trainer) - the female protagonist of Pokémon X and Y.
Additionally, there are two separate Serena characters from the Dragon Quest series:
- Serena (Dragon Quest IX) - a purple-dressed character from Dragon Quest IX: Sentinels of the Starry Skies.
- Serena (Dragon Quest XI) - a green-dressed character from Dragon Quest XI: Echoes of an Elusive Age.