The GameCube version features thirty monsters and seven cities such as New York City, Tokyo, and London. It features a four-player mode which has multiple options from which to choose. The game also features full emulations of the original arcade game Rampage and the Nintendo 64 game Rampage: World Tour.
The Wii version features Wii Remote motion controls, ten additional monsters, new super moves, and slightly updated graphics.
Overall, Rampage: Total Destruction was given fair to poor reviews. The Wii version received poorer reviews than the GameCube version, mostly due to the motion controls.