RAD is a roguelike game played from an isometric perspective. In the game, players control a teenager whose goal is to explore a procedurally-generated wasteland for effigies known as respirators, items that may restore the human civilizations after a devastating apocalypse. As the character explores the wasteland, their genes will mutate, granting players additional powers and perks. For each character, players can have unlimited passive bonuses and at most three active mutations. If the player character dies, they will be replaced by a new character.