The following are a list of games that have been confirmed to be present at E3 2010.
505 Games
- Grease - Nintendo DS, Wii
D3 Publisher
- Ben 10: Ultimate Alien - Wii
- Ben 10: Ultimate Alien: Cosmic Destruction - Nintendo DS
Disney Interactive
- Guilty Party - Wii
Electronic Arts
- EA Sports Active 2.0, Wii
- FIFA Soccer 11 - Wii, Nintendo DS
- Madden NFL 11 - Wii
- NBA Jam - Wii
- Tiger Woods PGA Tour 11 - Wii
Hudson Soft
- Bomberman Live: Battlefest' - Wii
- Bonk: Brink of Extinction - Wii
- Decca Sports 3 - Wii
- Lost in Shadow - Wii
- Oops! Prank Party - Wii
Konami
- Def Jam Rapstar - Wii
- The Cages: Pro Style Batting Practice - Wii
LucasArts
- LEGO Star Wars III: The Clone Wars - Nintendo DS, Wii
- Star Wars: The Force Unleashed II - Nintendo DS, Wii
MTV Games
- Rock Band 3 - Wii
Majesco
- Crafting Mama - Nintendo DS
- Graig Hastings Paintball 2 - Wii
- Swords - Wii
Namco Bandai
- Dragon Ball: Origins 2 - Nintendo DS
Natsume
- Harvest Moon Grand Bazaar - Nintendo DS
- Lufia: Curse of the Sinistrals - Nintendo DS
Nintendo
- The Legend of Zelda: Skyward Sword - Wii
- Nintendo 3DS
- Vitality Sensor
- Metroid Other M - Wii
- Kirby's Epic Yarn - DS
- Pokemon Ranger: Guardian Signs - DS
- Nintendogs + Cats - DS
- Kid Icarus: Uprising - DS
- New Animal Crossing - 3DS
- New Mario Cart - 3DS
- New Paper Mario - 3DS
- PilotWings Resort - 3DS
- Star Fox 64 3D - 3DS
- Steel Diver - 3DS
SEGA
- Conduit 2 - Wii
- Sonic the Hedgehog 4: Episode 1 - WiiWare
- Tournament of Legends - Wii
- Sonic Colors - Wii/DS
Slang
- Lucha Libre AAA: Heroes del Ring
THQ
- The Last Airbender: The Movie - Nintendo DS, Wii
Warner Bros. Interactive
- Batman: The Brave and the Bold - Nintendo DS, Wii
- Cats & Dogs: The Revenge of Kitty Galore - Nintendo DS
- LEGO Harry Potter: Years 1-4 - Nintendo DS, Wii
- Super Scribblenauts - Nintendo DS
- The Lord of the Rings: Aragorn's Quest - Nintendo DS, Wii
Community content is available under CC-BY-SA unless otherwise noted.