The game will be developed by a team led by Kensuke Tanabe. Metroid Prime 4 "returns to the first-person adventure roots of the original Metroid Prime game and introduces a storyline that ties together the events of the Metroid Prime universe and takes the storyline in new directions." The game was announced on the same day Metroid: Samus Returns was at E3.
The release date was given by Bill Trinen as "beyond 2017". VentureBeat initially quoted Charlie Schibetta, Nintendo of America's corporate communications director, saying that Metroid Prime 4 would be released in 2018, before retracting that statement and clarifying he meant "2018 and beyond".
On January 25, 2019, a video from Nintendo was posted to YouTube to give fans an update on the development of the game. Shinya Takahashi announced that what was developed so far did not feel like a true Metroid Prime sequel the fans are hoping for. Thus, it was announced that the development process would be restarted entirely, with Retro Studios collaborating in development.