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The Master Brain is the main antagonist and the final boss of Metroid Prime: Federation Force.
| Final bosses in Metroid | |
|---|---|
| Metroid series | Mother Brain • Queen Metroid • SA-X • Omega Metroid • Ridley Robot • Melissa Bergman • Phantoon • Proteus Ridley • Raven Beak |
| Metroid Prime series | Metroid Prime • Emperor Ing • Dark Samus • Gorea • Aurora Unit 313 • Master Brain • Samus Aran |