Game & Watch Gallery 4 (known as Game & Watch Gallery Advance in Europe and Australia, and as Game Boy Gallery 4 in Japan before it was cancelled) is the fifth and so far most recent game in the Game Boy Gallery/Game & Watch Gallery series. It was released in 2002, and was both published and developed by Nintendo, along with TOSE. The game features classic Game & Watch games, with both the original and a remake with Mario characters, items, worlds, and is usually more easy to understand what is going on in the gameplay. It also has two-player play, which was first introduced in Game & Watch Gallery 3 for the Game Boy Color.

It has a total of 10 games that can be playable both with a remade version, and the classic version, and has 9 games that can only be playable the classic way.

This collection has the most games of any in the series.