Dr. Mario Online Rx (JP) is a WiiWare video game initially released in 2008. The game was released in the WiiWare's launch window, and is basically a Dr. Mario remake featuring plenty of extras including online play and Virus Buster, a mini-game that was featured in Brain Age 2 for the Nintendo DS.

Players are allowed to use their Miis instead of Dr. Mario, even while playing online.


In the main game, players must drop pills on viruses bellow in order to destroy them. In all, there are three different colored viruses, and to kill one you'll have to drop three pill segments on top of a virus of the same color in order to destroy it. Each pill has two separate or same colored segments.

Once you complete a level, you'll be required to go to the next, which will inevitably be harder than the previous puzzle.


In the game, the four musical tracks: "Fever", "Chill", "Cube", and "Que Que" (the latter two tracks are now named "Cough" and "Sneeze" are included. Flash Mode, challenges the player(s) to clear just three flashing viruses among many, also returns from Dr. Mario 64.Virus Buster, previously seen as a mini-game in Brain Age 2 has more customization than the original. Whereas the original only had Easy, Normal, and Hard as options, this version allows to adjust virus level and music as well. Remixed versions of "Fever" and "Chill" are present in this mode. Virus Buster can be played alone or with others, with up to four players. Instead of being controlled directly with the D-pad, they are guided with the Wii Remote pointer.

In single player mode, a player can start the game at level 20. After winning level 20, levels 21, 22, and 23 increment by four viruses. Level 24 and beyond contain 99 viruses. After 99 levels, gameplay can continue but the game won't progress past level 99 and the player is shown with only the "Try Again" and "Quit" menu options.

Players played online against a friend with only one copy, as an online-play demo could be sent akin to DS Download Play. Vs. Mode could also be played offline, if desired.

Other Translations

Language / Region: Translates to:
Europe / Austrailia Dr. Mario & Germ Buster


IGN gave Dr. Mario Online Rx an 8.5/10, calling the main game "timeless" and the new Virus Buster mode "chaotically awesome". However they were disappointed by the fact that the main Dr. Mario mode only supported up to 2 players (where some earlier games had supported up to 4) and that Virus Buster was not playable online.

Additionally, N-Europe awarded Dr. Mario an 8/10, calling it "the same Dr. Mario that we know and love" with "solid and functional graphics" and addictive gameplay. GamesRadar gave it 6/10, calling it a "slightly awkward puzzler" that "just isn't addictive enough to make you care" and likened it to "Puyo Puyo's in-bred cousin". However, they praised the online multiplayer functionality and enjoyed its clean presentation, with the exception of the music.

NGamer also criticised the gameplay, and gave it 2/5.

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