Dr. Mario Express is a DSiWare video game released in 2008 in Japan and 2009 in North America and Europe. The game is a variation of Dr. Mario, and was probably created due to the overwhelming response of Dr. Mario Online Rx on WiiWare. The game costs 500 Nintendo Points, or $5.


It looks and acts the same as Dr. Mario from the NES, opens with Start or Help to select, when Start is pressed you get the options: Classic, Vs. CPU, Options, How To Play (same as help), and Records (High Scores). Classic Starts you on Level 10, Med speed, with Music track Fever, you can change any of these then hit OK to start. Pretty much the same as the online 8 bit version from Nintendo's site.

Other Translations

Language / Region: Translates to:
Japan / Europe / Austrailia A Little Bit of... Dr. Mario or

Hey Dr. MARIO (ちょっとDr. MARIO, Chotto Dr. Mario)

Spanish / French / Italian A Pause with... Dr. Mario
German Dr. Mario in Between


Dr. Mario Express received positive reviews with scores of 78.33% and 76on GameRankings and Metacritic. Daemon Hatfield of IGN scored the game 7.5 out of 10, stating the single-player experience is "solid" but "the lack of multiplayer hinders its lifespan."

Pocket Gamer awarded Dr. Mario Express 7 out of 10 along with a Bronze Award.


  • When the player beats level 5, 10, 15 or 20, they will see a picture of Dr. Mario sleeping under a tree. The number of viruses on top of the tree and the time of day depends on the speed and level the player plays at.
  • According to the Tetris and Dr. Mario instruction manual for the SNES, the Red Virus is female. This information is absent from the normal Dr. Mario instruction manual for the NES.
  • If the player destroys four or more viruses at once, a hidden Super Mario Bros. theme will play. This only works on the Game Boy version.
  • The 1989 prototype of Dr. Mario is the earliest known build of the game, and at this point in development was called 'Virus'. The prototype has numerous differences from the final version of the game.
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