Dr. Mario 64 is a sequel to the popular Nintendo Entertainment System and Game Boy classic Dr. Mario. It is the final Mario game to be released on the Nintendo 64, which had started with Super Mario 64, seven months before the release of Luigi's Mansion on the Nintendo GameCube - it was also only available in North America. In 2003, it was re-released along with Panel de Pon and Yoshi's Cookie in a Japan-only GameCube game called Nintendo Puzzle Collection. In 2005, Dr. Mario & Puzzle League was released, with the Dr. Mario portion mostly taking visual and audio cues from the 64 version.




The game features Mario as he tries to kill viruses by matching a certain number of pill of the same color together. Other characters also include Wario and Metal Mario, the later being from Super Mario 64 and the former from multiple other Mario video games. The gameplay is similar to the previous Dr. Mario games, which is understandable. Despite having the same classic gameplay that made the original so popular, the 64 port was not as well received.


Vampire Wario, a variation of the regular Wario, is an unlockable character. To obtain the character, the player will have to play and defeat single player mode on normal or higher without losing once. Metal Mario is also unlockable, and to unlock him, Dr. Mario will have to do the same tactic as he did with Vampire Wario, though the player will have to use Wario to beat the game.



Overall, Dr. Mario 64 received mostly positive reviews. GameRankings gave the game a score of 70.03%, while Metacritic gave it a score of 71/100. GameSpot also gave the game a 7.0/10. Dr. Mario 64 was voted #76 in the Top 100 Games of All Time poll published by Game Informer Magazine in August 2001.

References to other games

  • Dr. Mario - The basic formula for the Dr. Mario series is carried on from this game.
  • Super Mario 64 - Power Stars are used as indicators for whenever a character wins a match. When Dr. Mario wins, he spins and puts up a peace sign the way Mario does when he acquires a Power Star in Super Mario 64. Metal Mario (as both a powered-up form of Dr. Mario and a secret unlockable character) is a power-up from this game.
  • Wario Land 3 - All the characters apart from Dr. Mario, Metal Mario, and the Viruses are from this game.

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