Dr. Mario is a series of puzzle games by Nintendo featuring the character himself named Dr. Mario using Megavitamins to clear viruses. It plays similar to Tetris, though with the goal to match 4 of the same colored pieces with one of the pieces being a virus.


References in other media

Super Smash Bros.

The series includes the character, Dr. Mario as a part of the roster in Super Smash Bros. Melee and in Super Smash Bros. for Nintendo 3DS and Wii U.

Melee also included a synthesized version of the Fever theme that alternatively played on Mushroom Kingdom and Mushroom Kingdom II. This song returned on PictoChat in Brawl and the 3DS version. Brawl also had a metal version of Chill played on Flat Zone 2. Both these songs returned in the Wii U version on the Flat Zone X. The Wii U version also has a new remix of Chill that plays on 75m.

Brawl also had stickers of Dr. Mario, a Capsule, and all three Viruses. They are listed under Nintendo Puzzle Collection.


In WarioWare, Inc.: Mega Microgame$!, there is an unlockable minigame called Dr. Wario. This is a modified rendition of Dr. Mario for the NES.

Brain Age

Brain Age 2 includes a minigame called Virus Buster which is essentially a touch-based simpler version of Dr. Mario. This mode was later integrated into future versions of Dr. Mario.