Claire is a survivor of the Raccoon City Incident, which took place in September 1998 after she traveled to the city in search of her brother Chris Redfield. After escaping the city with the help of Leon S. Kennedy, Claire ventured to Europe to continue her search for Chris. In December, she was captured by Umbrella after infiltrating their Paris Laboratory and transported to the Umbrella owned Rockfort Island and imprisoned. When Rockfort Island was attacked by a mysterious Special Forces group, Claire tried to escape with a fellow prisoner, Steve Burnside, leading to both of their involvements in the Antarctic outbreak. Her brother soon learned of her situation and rescued her. In 2005, Claire confronted the t-Virus again when she arrived at Harvardville Airport to meet some friends. While surviving in the airport, she was reunited with Leon, now a U.S. Government agent, who had been sent to deal with the outbreak.