Chris Redfield is an American soldier within the Bioterrorism Security Assessment Alliance from Resident Evil, of which he has served since its foundation in 2003. Redfield has built up a career in destroying bioweapons and fighting the producers and sellers of bioweapons, starting with the Mansion Incident of 1998. He is the older brother of TerraSave member, Claire Redfield.

Chris Redfield debuted in the original Resident Evil as one of the playable protagonists, along with Jill Valentine, partnered with the rookie officer Rebecca Chambers. He is introduced as a former U.S. military pilot hailing from New York City, and a member of the Raccoon City Police Special Tactics And Rescue Service's (STARS) Alpha team, sent to investigate the disappearance of Bravo team after their helicopter goes missing in a nearby forest. Chris, accompanied by Jill, Albert Wesker, and Barry Burton, soon find themselves trapped in a nearby mansion, filled with horrific monsters and deadly traps. Chris' scenario is more challenging than Jill's, as he has a smaller carrying capacity and lacks certain items. Unlike Jill, he is not equipped with a lock-pick and needs to find keys. He can take a lot more physical damage from enemies than she can. In the end, Chris and his comrades learn how the incident began, and witness the death of Albert Wesker, who was betraying them all along. They also face and kill a prototype Tyrant released by Wesker. Following the so-called "Mansion Incident", Chris leaves Raccoon City, embarking on a personal mission against the Umbrella Corporation, after learning of how Umbrella instigated the viral outbreak in the mansion.

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